The decision follows the findings of the Global Travel Taskforce, set up by the UK government to examine how non-essential travel could be reopened safely after lockdown.
Securing air service to a hub is a key target for City of Derry (LDY) as the Northern Irish airport seeks to rebuild connectivity in the wake of the pandemic.
Three Airbus A320s will be stationed at Berlin Brandenburg from April, while in May the Lufthansa-owned carrier intends to begin flying between the UK and Mallorca.